Establishment and characterization of amitrole-induced mouse thyroid adenomatous nodule-derived cell lines

Conclusion Two mouse thyroid adenomatous nodule-derived cell lines with different thyroid differentiation marker expression were established. NKX2-1 induced partial differentiation of these cell lines. They lacked tumorigenicity and prominent gene mutations involved in thyroid cancer development, while missense mutations were found in some tumor suppressors as revealed by WGS. The CAT458s and 459 provide a new tool to further clarify the process of thyroid multi-step carcinogenesis and differentiation.PMID:38149583 | DOI:10.1089/thy.2023.0341
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Authors: Source Type: research