Increased IGFBP proteolysis, IGF-I bioavailability and pappalysin levels in children with Prader-Willi syndrome

CONCLUSION: The increase in PAPP-A could be involved in increased IGFBP proteolysis, promoting IGF-I bioavailability in children with PWS. Further studies are needed to establish the relationship between growth, GH resistance, and changes in the IGF axis during development and after GH treatment in these patients.PMID:38141219 | DOI:10.1210/clinem/dgad754

Source: The Journal of Clinical Endocrinology and Metabolism - December 23, 2023 Category: Endocrinology Authors: Vicente Barrios Álvaro Martín-Rivada Gabriel Á Martos-Moreno Sandra Canelles Francisca Moreno-Maci án Carmen De Mingo-Alemany Maurizio Delvecchio Roberta Pajno Danilo Fintini Julie A Chowen Jes ús Argente Source Type: research