Anti-EJ antibody-positive interstitial pneumonia with breast cancer improved by combining immunosuppressive therapy and chemotherapy

We present a case of a 45-year-old woman diagnosed with interstitial pneumonia (IP) during a comprehensive breast cancer evaluation. Although the patient showed no obvious clinical symptoms of polymyositis or dermatomyositis, the presence of anti-glycyl-transfer ribonucleic acid synthetase antibodies confirmed anti-synthetase syndrome. The patient began methylprednisolone for treatment of the IP. She then received preoperative chemotherapy with epirubicin and cyclophosphamide before undergoing a mastectomy. A significant improvement was seen in the patient's IP during treatment. This case emphasizes the potential advantages of personalized immunosuppressive therapy for patients who are simultaneously diagnosed with anti-synthetase syndrome and cancer.PMID:38124994 | PMC:PMC10730374 | DOI:10.1016/j.rmcr.2023.101950

Source: Respiratory Care - December 21, 2023 Category: Respiratory Medicine Authors: Ai Koike Masako Arimura-Omori Shuyo Umeda Akihisa Takano Yasuyuki Kishikawa Satoshi Nakamura Yuriko Takahata Yuki Okamatsu Akitaka Fujita Taishi Harada Source Type: research