A case of idiopathic multicentric Castleman's disease with secondary autoimmune neutropenia

Thrombocytopenia and anaemia are common complications of Idiopathic multicentric Castleman's disease (iMCD)-induced hematologic disorders, however, neutropenia associated with iMCD is rare. The association between iMCD and autoimmune neutropenia (AIN) involving anti-neutrophil antibodies has not yet been elucidated. Here, we present the first case report of iMCD complicated by secondary AIN with positive anti-neutrophil antibodies. AbstractA 73-year-old Japanese woman with productive cough and dyspnoea on exertion was admitted, and she showed neutropenia and pulmonary reticular opacities and axial and mediastinal lymphadenopathies on chest computed tomography. The clinical findings and surgical lung and lymph node biopsies were diagnostic for idiopathic multicentric Castleman's disease (iMCD) complicated by secondary autoimmune neutropenia (AIN). iMCD is often complicated with hematologic disorders, however, iMCD complicated with AIN has not been reported; therefore, if iMCD is accompanied by neutropenia, the anti-neutrophil antibodies should be measured.
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: CASE REPORT Source Type: research