Immunogenicity and safety of varying dosages of a fifth-wave influenza A/H7N9 inactivated vaccine given with and without AS03 adjuvant in healthy adults

CONCLUSIONS: AS03 adjuvant improved the immune responses to an inactivated fifth-wave H7N9 influenza vaccine, particularly in younger adults, but invoked lower responses to drifted H7N9 strains. These findings may inform future influenza pandemic preparedness strategies.PMID:38105137 | DOI:10.1016/j.vaccine.2023.12.001

Source: Vaccine - December 17, 2023 Category: Allergy & Immunology Authors: Lisa A Jackson Jack T Stapleton Emmanuel B Walter Wilbur H Chen Nadine G Rouphael Evan J Anderson Kathleen M Neuzil Patricia L Winokur Michael J Smith Kenneth E Schmader Geeta K Swamy Amelia B Thompson Mark J Mulligan Christina A Rostad Kaitlyn Cross Rach Source Type: research