Transforming growth factors β and their signaling pathway in renal cell carcinoma and peritumoral space—transcriptome analysis

ConclusionOn the one hand, the underexpression of the TGF β signaling pathway genes within the malignant tumor may result in the loss of the antiproliferative and pro-apoptotic activity of this cytokine. On the other hand, the overexpression of the TGFβ/Smads pathway genes in the TME than in tumor or NK tissues most probably results in an immunosuppressi ve effect in the space surrounding the tumor and may have an antiproliferative and pro-apoptotic effect on non-neoplastic cells present in the TME. The functional and morphological consistency of this area may determine the aggressiveness of the tumor and the time in which the neoplastic process wil l spread.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research