Presumed Pathogenic Germline and Somatic Variants in African American Thyroid Cancer
CONCLUSION: In this cohort, most AA-NMTC patients exhibit favorable outcomes after therapeutic intervention given at cancer centers, suggesting that healthcare disparity is the major contributor for worse prognoses among AA-NMTC patients. Nevertheless, the clinical impact of PPGVs that might facilitate acquisition of TP53 tumor mutations, and/or PPGVs that predispose individuals to adverse cardiovascular events which could be exacerbated by therapy-induced cardiotoxicity, need to be further explored. Integrated analysis of PPGV/PPSV profiles among NMTC patients with different stages of disease may help to identify NMTC patients who require close monitoring or proactive intervention.PMID:38062767 | DOI:10.1089/thy.2023.0487
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Authors: Zachary A Hurst Sandya Liyanarachchi Pamela Brock Huiling He Fadi Nabhan Colleen Veloski Amanda E Toland Matthew D Ringel Sissy M Jhiang Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Cardiology | Cardiovascular | Endocrinology | Genetics | Heart | Thyroid | Thyroid Cancer