Folic acid-functionalized chitosan nanoparticles with bioenzyme activity for the treatment of spinal cord injury
Eur J Pharm Sci. 2023 Dec 5:106667. doi: 10.1016/j.ejps.2023.106667. Online ahead of print.ABSTRACTSpinal cord injury (SCI) is a central system disease with a high rate of disability. Pathological changes such as ischemia and hypoxia of local tissues, oxidative stress and apoptosis could lead to limb pain, paralysis and even life-threatening. It was reported that catalase (CAT) was the main antioxidant in organisms, which could remove reactive oxygen species (ROS) and release oxygen (O2). However, the efficacy of the drug is largely limited due to its poor stability, low bioavailability and inability to cross the blood spinal cord barrier (BSCB). Therefore, in this study, we prepared folic acid-functionalized chitosan nanoparticles to deliver CAT (FA-CSN-CAT) for solving this problem. In vivo small animal imaging results showed that FA-CSN could carry CAT across the BSCB and target to the inflammatory site. In addition, Immunofluorescence, ROS assay and JC-1 probe were used to detect the therapeutic effect of FA-CSN-CAT in vitro and in vivo. The results showed that FA-CSN-CAT could alleviate the hypoxic environment at the injured site and remove ROS, thereby inhibiting oxidative stress and protecting neurons, which may provide a new idea for clinical medication of SCI.PMID:38061663 | DOI:10.1016/j.ejps.2023.106667
Source: European Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Authors: Yingqiao Li Zhiru Zou Jinyu An Xiaoyao Liu Qian Wu Junpeng Sun Xiaobang Liu Jiaqun Du Ying Xiong Chao Wu Xifan Mei He Tian Source Type: research
More News: Antidoxidants | Back Pain | Brain | Disability | Drugs & Pharmacology | Environmental Health | Folic Acid | Nanotechnology | Neurology | Pain | Spinal Cord Injury | Study | Vitamin B9