A HIF-1 α inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells

ConclusionsA combination therapy of YC-1 with PA  + LC may be a unique anti-tumor therapy for targeting hypoxic HCC cells, specifically by ROS overproduction leading to forced FAO activation.
Source: Cancer and Metabolism - Category: Cancer & Oncology Source Type: research