Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination

This study demonstrated a statistically significant reduction in alpha diversity and a shift in gut microbiota composition following BNT162b2 vaccination, characterised by reductions in Actinobacteriota, Blautia, Dorea, Adlercreutzia, Asacchaobacter, Coprococcus, Streptococcus, Collinsella and Ruminococcus spp and an increase in Bacteroides cacaae and Alistipes shahii. Our prospective observational study (n=52; figure 1A, ) similarly showed a shift in gut microbiota after the first BNT162b2 vaccine dose (p=0.016; ), including a reduction in Actinobacteria, Blautia spp (p<0.01; figure 1B), and alpha diversity (p=0.078; ). Our data support the findings by Ng et al,1 reinforcing the link between SARS-CoV-2 mRNA vaccine immunogenicity and the gut microbiota. Ng et al1 also identified strong associations between baseline gut microbiota composition and serological IgG responses...
Source: Gut - Category: Gastroenterology Authors: Tags: Open access, Gut, COVID-19 PostScript Source Type: research