Molecular landscape of proliferative verrucous leukoplakia: A systematic review

Proliferative verrucous leukoplakia (PVL) is a rare oral potentially malignant disorder characterised by multifocal origin and unpredictable long-term evolution to oral squamous cell carcinoma (OSCC) or oral verrucous carcinoma (OVC). There are currently no predictive biomarkers in clinical use. We aim to explore the genomic profile of PVL. 685 cases in 26 studies were included in this review. Genomic data were presented in 15% of studies and biomarker analysis in 85% of studies.At first clinical presentation, PVL is characterised by high Loss of Heterozygosity (LOH) similar to OSCC and low copy number alterations (CNA).
Source: The British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Systematic review Source Type: research