The transcriptomic profile shows the protective effects of celecoxib on cirrhotic splenomegaly

CONCLUSIONS: Celecoxib attenuates cirrhotic splenomegaly by inhibiting splenic immune cell proliferation, inflammation, and fibrogenesis. The current study sheds light on the therapeutic strategy of liver cirrhosis by targeting splenic abnormalities and provides COX-2 inhibitors as a novel medical treatment for cirrhotic splenomegaly.PMID:38047472 | DOI:10.1080/08923973.2023.2281282

Source: Immunopharmacology and Immunotoxicology - December 4, 2023 Category: Allergy & Immunology Authors: Yanting Ye Shihang Tang Yang Tai Chong Zhao Chengwei Tang Zhiyin Huang Jinhang Gao Source Type: research