IRX2 regulates endometrial carcinoma oncogenesis by transcriptional repressing RUVBL1

In conclusion, our findings indicate that decreased expression of IRX2 facilitates EC cell growth through the regulation of RUVBL1 expression, thereby contributing to the development of EC. Hence, targeting the IRX2-RUVBL1 axis holds promise as a potential therapeutic strategy for EC treatment.PMID:38042247 | DOI:10.1016/j.yexcr.2023.113866

Source: Experimental Cell Research - December 2, 2023 Category: Cytology Authors: Qinyang Xu Wanzhen Zhou Yuedi Zhou Xueying Zhang Rongzhen Jiang Zhihong Ai Jing Chen Li Ma Source Type: research