Serotonergic agonism and pharmacologically-induced adolescent stress cause operant-based learning deficits in mice

CONCLUSION: Whilst we revealed dissociable detrimental effects of adolescent CORT treatment and acute 5-HT1A/1B receptor agonism on discrimination and reversal learning, respectively, we did not find evidence of additive deleterious effects of these two treatments. We therefore suggest that while disrupted serotonergic signalling is likely to be involved in the cognitive phenotype of OC-spectrum disorders, distinct neuropathological pathways may be at play in mediating the role of stress as an antecedent in OCD and related illnesses.PMID:38040286 | DOI:10.1016/j.neuropharm.2023.109801
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research