Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia

DISCUSSION: Results show that greater regional WMH volume relates to poorer cognitive functioning-even among those with normal cognition. Together with results from previous studies, our findings raise the possibility that WMH may be a useful therapeutic target and/or important effect modifier in treatment or prevention dementia trials.PMID:38015423 | PMC:PMC10664788 | DOI:10.1097/WAD.0000000000000585

Source: Alzheimer Disease and Associated Disorders - November 28, 2023 Category: Psychiatry Authors: Rachel Membreno Kelsey R Thomas Amanda T Calcetas Lauren Edwards Maria Bordyug Maya Showell Morgan Stanfill Einat K Brenner Kayla S Walker Lindsay J Rotblatt Adam M Brickman Emily C Edmonds Katherine J Bangen Alzheimer ’s Disease Neuroimaging Initiative Source Type: research