Multiscale biophysical models of cardiomyopathies reveal complexities challenging existing dogmas

Biophys J. 2023 Nov 24:S0006-3495(23)00714-2. doi: 10.1016/j.bpj.2023.11.014. Online ahead of print.ABSTRACTMutations in sarcomeric proteins, including myosin, cause a variety of cardiomyopathies. A prominent hypothesis has been that myosin mutations causing hypercontractility of the motor lead to hypertrophic cardiomyopathy, while those causing hypocontractility lead to dilated cardiomyopathy; however, recent biophysical studies using multiscale computational and experimental models have revealed complexities not captured by this hypothesis. We summarize recent publications in Biophysical Journal challenging this dogma and highlighting the need for multiscale modeling of these complex diseases.PMID:38006882 | DOI:10.1016/j.bpj.2023.11.014
Source: Biophysical Journal - Category: Physics Authors: Source Type: research