VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis

This study reveals unexpected therapeutic benefits of VEGFA delivered via nucleoside-modified mRNA-LNP, whose safety is widely validated with COVID-19 vaccines, for harnessing BEC-driven repair to potentially treat liver diseases.PMID:38029740 | DOI:10.1016/j.stem.2023.10.008

Source: Cell Stem Cell - November 29, 2023 Category: Stem Cells Authors: Fatima Rizvi Yu-Ri Lee Ricardo Diaz-Aragon Pushpinder S Bawa Juhoon So Rodrigo M Florentino Susan Wu Arianna Sarjoo Emily Truong Anna R Smith Feiya Wang Elissa Everton Alina Ostrowska Kyounghwa Jung Ying Tam Hiromi Muramatsu Norbert Pardi Drew Weissman Al Source Type: research