A multi-site phase I trial of Veliparib with standard radiation and temozolomide in patients with newly diagnosed glioblastoma multiforme (GBM)

ConclusionsAlthough Veliparib 10  mg BID administered with TMZ 75 mg/m2 for six weeks was well tolerated, when this regimen was combined with standard partial brain irradiation it was severely myelosuppressive even when the dose was reduced by 50%. This study again highlights the potential of localized cranial radiotherapy to sig nificantly increase hematologic toxicity of marginally myelosuppressive systemic therapies.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research