CTHRC1 promotes colorectal cancer progression by recruiting tumor-associated macrophages via up-regulation of CCL15

In conclusion, CTHRC1 could promote the chemotactic ability of macrophages by up-regulating CCL15 via TGFβ/Smad pathway; additionally, a high level of CTHRC1 could promote macrop hage’s M2 polarization. This discovery may be related to tumor immune tolerance and tumor immunotherapy resistance in CRC.Key messagesCTHRC1 promotes CRC progression by up-regulating CCL15 via TGF- β/Smad pathways to further recruit tumor-associated macrophages.By the means of autocrine or paracrine, CTHRC1 can indeed promote macrophage chemotaxis and enhance the infiltration of macrophages in tumor tissues but in the presence of tumor cells.CAFs were another source of CTHRC1, indicating CTHRC1 can infiltrate tumor islet as well as the stomal and be secreted from both tumor cells and CAFs.This study validated CTHRC1 as a potential immune therapy target CRC.
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research