Genomic and transcriptomic advances in amyotrophic lateral sclerosis

We report the most relevant genes implicated in ALS pathogenesis, discussing the use of different high-throughput sequencing techniques and the role of epigenomic modifications. Furthermore, we present transcriptomic studies discussing the most recent advances, from microarrays to bulk and single-cell RNA sequencing. Finally, we discuss the use of microRNAs as potential biomarkers and promising tools for molecular intervention. The integration of data from multiple omic approaches may provide new insights into pathogenic pathways in ALS by shedding light on diagnostic and prognostic biomarkers, helping to stratify patients into clinically relevant subgroups, revealing novel therapeutic targets and supporting the development of new effective therapies.PMID:37972860 | DOI:10.1016/j.arr.2023.102126

Source: Ageing Research Reviews - November 16, 2023 Category: Genetics & Stem Cells Authors: Mafalda Rizzuti Luca Sali Valentina Melzi Simone Scarcella Gianluca Costamagna Linda Ottoboni Lorenzo Quetti Lorenzo Brambilla Dimitra Papadimitriou Federico Verde Antonia Ratti Nicola Ticozzi Giacomo Pietro Comi Stefania Corti Delia Gagliardi Source Type: research