Agathis dammara Extract and its Monomer Araucarone Attenuate Abdominal Aortic Aneurysm in Mice

ConclusionsThrough suppressing NF- κB/NLRP3 pathway activation, AD effectively mitigates the inflammatory response in VSMCs, mitigates inflammation in aortas, prevents extracellular matrix degradation, and consequently impedes the progression of AAA. AO emerges as one of the active compounds in AD responsible for inhibiting VSMC inf lammation and inhibiting AAA development.
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research