Diagnosis and Management of Noncirrhotic Portal Hypertension

This article aims to provide an update on the pathologic, clinical, diagnostic, and therapeutic aspects of this underrecognized disease.Recent FindingsThe diagnosis of PSVD requires a liver biopsy. Specific histology findings include nodular regenerative hyperplasia, obliterative portal venopathy or portal vein stenosis, and incomplete septal fibrosis/cirrhosis. The natural history of PSVD has not been elucidated, and screening guidelines for sequalae such as portal hypertension or portal vein thrombosis and the outcome of liver transplantation in these patients are unclear.SummaryPatients who have signs of portal hypertension despite unremarkable work-up for portal vein thrombosis and cirrhosis should be actively evaluated for PSVD. A heightened awareness of PSVD as a novel clinical entity should facilitate further collaborative studies and investigations.
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research