The association of incidental radiation dose to the heart base with overall survival and cardiac events after curative-intent radiotherapy for non-small cell lung cancer: results from the NI-HEART Study

Cardiac disease is a dose-limiting toxicity in non-small cell lung cancer radiotherapy. The dose to the heart base has been associated with poor survival in multiple institutional and clinical trial datasets using unsupervised, voxel-based analysis. Validation has not been undertaken in a cohort with individual patient delineations of the cardiac base or for the endpoint of cardiac events. The purpose of this study was to assess the association of heart base radiation dose with overall survival and the risk of cardiac events with individual heart base contours.

Source: Clinical Oncology - November 13, 2023 Category: Radiology Authors: Gerard M. Walls, John O ’Connor, Mark Harbinson, Frances Duane, Conor McCann, Peter McKavanagh, David I. Johnston, Valentina Giacometti, Jonathan McAleese, Alan R. Hounsell, Aidan J. Cole, Karl T. Butterworth, Conor K. McGarry, Gerard G. Hanna, Suneil J Tags: Original Article Source Type: research