The relationship between the intestinal microbiome and body mass index in children with cystic fibrosis

Cystic fibrosis (CF) is a life-limiting disease caused by defects in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that controls the movement of chloride across epithelial cell membranes and results in thick mucus accumulation [1]. Although historically considered a pulmonary disease, gastrointestinal conditions cause significant morbidity in children with CF [2]. Many also have growth and nutritional failure often measured by low body mass index percentile (BMIp), despite therapy with pancreatic enzymes, vitamin replacement, and increased calorie intake [3].

Source: Journal of Cystic Fibrosis - November 11, 2023 Category: Respiratory Medicine Authors: Rachel Bernard, Meghan H. Shilts, Britton A. Strickland, Helen H. Boone, Daniel C. Payne, Rebekah F. Brown, Kathryn Edwards, Suman R. Das, Maribeth R. Nicholson Tags: Original Article Source Type: research