Association between Parental BMI and Offspring's Blood pressure by Mediation analysis, From Korean National Health and Nutrition Examination Survey (KNHANES)

This study analyzed the relationship between parental BMI (BMI_p) and hypertension in their adolescent offspring (HTN_a), focusing on the mediating effect of adolescents' BMI(BMI_a). The study utilized data from the Korea National Health and Nutrition Examination Survey, including 5,755 participants aged 12-18, and conducted mediation analysis while controlling for confounding factors such as age, gender, physical activity, dietary habits, household income quartile, and parents' alcohol and smoking habits. The study included a total of 5,755 participants, with 3,401 and 5,485 participants having data on fathers' and mothers' BMI, respectively. For child systolic blood pressure (SBP_a), the father's BMI (BMI_f) had a significant total effect (ß=0.21, 95% CI 0.11-0.31) and average controlled mediated effect (ACME) (ß=0.27, 95% CI 0.24-0.21), but the average direct effect (ADE) was not significant. The mother's BMI (BMI_m) had a significant total effect (ß=0.18, 95% CI 0.10-0.26), ACME (ß=0.26, 95% CI 0.23-0.29) and ADE (ß=-0.08, 95% CI -0.16-0.00). For child diastolic blood pressure (DBP_a), both BMI_f and BMI_m had significant ACME (ß=0.10, 95% CI 0.07-0.13), (ß=0.10, 95% CI 0.08-0.12), but insignificant ADE and total effects. The study found that parents' BMI has a significant effect on the SBP_a when mediated through their BMI. Therefore, high BMI of parents is a significant risk factor for systolic hypertension in children and adolescents, which requires appropriate ...
Source: Journal of Preventive Medicine and Public Health - Category: International Medicine & Public Health Authors: Source Type: research