Assessing the causal association between dietary vitamin intake and lymphoma risk: a Mendelian randomisation study

Int J Food Sci Nutr. 2023 Nov 7:1-10. doi: 10.1080/09637486.2023.2278420. Online ahead of print.ABSTRACTObservational studies of diet-related vitamins and lymphoma risk results were inconsistent. Our study aimed to estimate the causality between dietary vitamin intake and lymphoma through a Mendelian randomisation (MR) study. We enrolled dietary-related retinol, vitamin C, vitamin E, vitamin B6 and vitamin B12 as exposures of interest, with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) as the outcome. The causal effects were estimated using inverse variance weighting (IVW), MR-Egger regression analysis and weighted median, supplemented by sensitivity analyses. The results revealed that genetically predicted dietary vitamin B12 intake was associated with a reduced HL risk (OR = 0.22, 95% CI 0.05-0.91, p = 0.036). The Q test did not reveal heterogeneity, the MR-Egger test showed no significant intercepts, and the leave-one-out (LOO) analysis did not discover any SNP that affect the results. No causal relationship about dietary vitamin intake on the NHL risk was observed.PMID:37933598 | DOI:10.1080/09637486.2023.2278420
Source: International Journal of Food Sciences and Nutrition - Category: Nutrition Authors: Source Type: research