Therapeutic Effects of Berberine against Urological Cancers: Biological Potentials Based on Cellular Mechanisms

Curr Mol Med. 2023 Nov 6. doi: 10.2174/0115665240263630231009050436. Online ahead of print.ABSTRACTUrological cancers, including prostate, kidney, and bladder cancer are problematic human diseases worldwide. Current strategies for the treatment of these cancers are chemotherapy, radiotherapy, surgery, or a combination of mentioned therapies. Due to the high mortality and morbidity rate of urological cancers and possible side effects of available standard treatments, searching for more effective and safe treatments is a critical issue. The beneficial properties of natural compounds, such as berberine, have been widely investigated in human diseases. Moreover, the anticancer potential of this agent has been extensively documented, especially in experimental studies. In this review, we have tried to discuss the effect of berberine against urological cancers, focusing on cellular and molecular mechanisms.PMID:37933211 | DOI:10.2174/0115665240263630231009050436
Source: Current Molecular Medicine - Category: Molecular Biology Authors: Source Type: research