CSF1R inhibition with PLX5622 affects multiple immune cell compartments and induces tissue-specific metabolic effects in lean mice

Conclusions/interpretationMacrophages and macrophage-derived factors, such as IL-1 β, play an important role in physiological insulin secretion. A better understanding of the tissue-specific effects of CSF1R inhibition on immune cells and glucose homeostasis is crucial for the development of targeted immune-modulatory treatments in metabolic disease.Data availabilityThe RNA-Seq dataset is available in the Gene Expression Omnibus (GEO) under the accession number GSE189434 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE189434).Graphical Abstract
Source: Diabetologia - Category: Endocrinology Source Type: research