Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT < sub > 2C < /sub > receptor in the mouse brain

CONCLUSIONS: Our findings reveal differential effects of 5-HT depletion and ethanol cessation on 5-HT2C receptor editing. Central 5-HT depletion attenuated editing in the prefrontal cortex and the hippocampus, whereas ethanol deprivation, coinciding with reduced Tph2 expression in the hippocampus, enhanced receptor editing efficiency specifically in this brain region. This study highlights the interplay between 5-HT synthesis, ethanol cessation, and 5-HT2C receptor editing, providing potential mechanism underlying increased ethanol consumption and deprivation.PMID:37923824 | DOI:10.1007/s43440-023-00545-6
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Source Type: research