Recent Development in the Search for Epidermal Growth Factor Receptor (EGFR) Inhibitors based on the Indole Pharmacophore

Curr Top Med Chem. 2023 Oct 31. doi: 10.2174/0115680266264206231020111820. Online ahead of print.ABSTRACTThe signal transduction and cell proliferation are regulated by the epidermal growth factor receptor. The proliferation of tumor cells, apoptosis, invasion, and angiogenesis is inhibited by the epidermal growth factor receptor. Thus, breast cancer, non-small cell lung cancer, cervical cancer, glioma, and bladder cancer can be treated by targeting the epidermal growth factor receptor. Although third-generation epidermal growth factor receptor inhibitors are potent drugs, patients exhibit drug resistance after treatment. Thus, the search for new drugs is being continued. Among the different potent epidermal growth factor receptor inhibitors, we have reviewed the indole-based inhibitors. We have discussed the structure-activity relationship of the compounds with the active sites of the epidermal growth factor receptor receptors, their synthesis, and molecular docking studies.PMID:37909440 | DOI:10.2174/0115680266264206231020111820

Source: Current Topics in Medicinal Chemistry - November 1, 2023 Category: Chemistry Authors: Shweta Mishra Adarsh Sahu Avneet Kaur Maninder Kaur Jayendra Kumar Pranay Wal Source Type: research