Consumption of sucralose- and acesulfame-potassium-containing diet soda alters the relative abundance of microbial taxa at the species level: findings of two pilot studies

We examined effects of three-times daily sucralose- and acesulfame-potassium-containing diet soda consumption for 1 (n  = 17) or 8 (n = 8) weeks on gut microbiota composition in young adults. After 8 weeks of diet soda consumption, the relative abundance of Proteobacteria, specifically Enterobacteriaceae, increased; and, increased abundance of two Proteobacteria taxa was also observed after 1 week of diet soda c onsumption compared with sparkling water. In addition, three taxa in the Bacteroides genus increased following 1 week of diet soda consumption compared with sparkling water. The clinical relevance of these findings and effects of sucralose and acesulfame-potassium consumption on human gut microbiota warrant further investigation in larger studies. Clinical trial registration: NCT02877186 and NCT03125356.

Source: Applied Physiology, Nutrition, and Metabolism - October 30, 2023 Category: Physiology Authors: Allison C. Sylvetsky Rebecca A. Clement Nathaniel Stearrett Najy T. Issa Fiona J. Dore Raja Mazumder Charles Hadley King Monica J. Hubal Peter J. Walter Hongyi Cai Sabyasachi Sen Kristina I. Rother Keith A. Crandall Source Type: research