The combination of the low immunohistochemical expression of peroxiredoxin 4 and perilipin 2 predicts longer survival in pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly playing a main role

In this study, we collected 101 patients' clinical data and paraffin-embedded specimens with PDAC and analyzed them with immunohistochemical staining of PRDX4 and PLIN2. We found that the low expression of PRDX4 predicts longer survival and a better clinical condition in PDAC patients. Moreover, when the low expression of PRDX4 is combined with the low expression of PLIN2, the 3-year survival is significantly improved. Univariate and multivariate Cox proportional hazard analyses showed that the PRDX4 expression in PDAC was an independent prognostic factor for survival. Taken together, between PRDX4 and PLIN2, PRDX4 plays a main role in prognosis and has the potential to become a clinical prognostic indicator of PDAC.PMID:37787446 | DOI:10.14670/HH-18-666

Source: Histology and Histopathology - October 3, 2023 Category: Cytology Authors: Jia Han Tohru Itoh Akihiro Shioya Masaru Sakurai Takeru Oyama Motona Kumagai Hiroyuki Takamura Masashi Okuro Tsuyoshi Mukai Hidekazu Kitakata Masaru Inagaki Michiyo Higashi Xin Guo Sohsuke Yamada Source Type: research