High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy

CONCLUSIONS: HFD may inhibit the expression of SIRT1/AMPK pathway and disrupt autophagy flux, and result in tau hyperphosphorylation and synaptic dysfunction during aging, which ultimately lead to cognitive decline.PMID:37898395 | DOI:10.1016/j.expneurol.2023.114591

Source: Experimental Neurology - October 28, 2023 Category: Neurology Authors: Wenmin Yi Fei Chen Minghao Yuan Chuanling Wang Shengyuan Wang Jie Wen Qian Zou Yinshuang Pu Zhiyou Cai Source Type: research