Design of a clinical trial using generalized pairwise comparisons to test a less intensive treatment regimen

CONCLUSION: Generalized pairwise comparisons allow for simultaneous assessment of efficacy and safety, with priority given to the former. The sample size required would be of the order of 300 patients, as compared with more than 700 patients for a non-inferiority trial using a margin of 4% against the less intensive treatment regimen for the absolute difference in event-free survival at 2 years, as considered here.PMID:37877379 | DOI:10.1177/17407745231206465

Source: Clinical Trials - October 25, 2023 Category: Research Authors: Micka ël De Backer Manju Sengar Vikram Mathews Samuel Salvaggio Vaiva Deltuvaite-Thomas Jean-Christophe Chi êm Everardo D Saad Marc Buyse Source Type: research