Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate ‑resistant human colorectal cancer cells

In conclusion, the present study revealed a novel mechanism involving MSH3 in the regulation of ecDNAs by DSB repair, which will have clinical value in the treatment of ecDNA‑based drug resistance in cancer.PMID:37888748 | DOI:10.3892/ijo.2023.5582

Source: International Journal of Oncology - October 27, 2023 Category: Cancer & Oncology Authors: Xu Wang Yanan Qu Ruonan Xing Jing Zhou Yanghe Liu Huishu Zhang Jing Zhu Jinfa Ma Xiaobo Cui Tiantian Song Shukai Xing Guohua Ji Peng Liu Wenjing Sun Songbin Fu Xiangning Meng Source Type: research