BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination

ConclusionBMP7 can alleviate TN by reducing OLs apoptosis and subsequent demyelination. The mechanism behind this protection could be BMP7-mediated activation of the STAT3 and NF- κB/p65 signaling pathway and subsequent decrease in OL apoptosis. Importantly, our study presents clear evidence in support of BMP7 as a possible therapeutic target for the treatment of TN.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research