MG53 alleviates hypoxia/reoxygenation-induced cardiomyocyte injury by succinylation and ubiquitination modification

CONCLUSION: SIRT7 inhibited/KAT3B promoted succinylation of MG53 at K130 sites, which suppressed ubiquitination of MG53 and upregulated its protein levels, thereby alleviating H/R-induced cardiomyocyte injury. The findings suggested that MG53 may be a potential therapy for myocardial infarction.PMID:37848382 | DOI:10.1080/10641963.2023.2271196
Source: Clinical and Experimental Hypertension - Category: Cardiology Authors: Source Type: research