Anti-amyloid potential of some phytochemicals against A β-peptide and α-synuclein, tau, prion, and Huntington proteins

Drug Discov Today. 2023 Oct 17:103802. doi: 10.1016/j.drudis.2023.103802. Online ahead of print.ABSTRACTSome molecules self-assemble to create complex structures through molecular self-assembly. Hydrogel preparation, tissue repair, and therapeutic drug delivery are a few applications of molecular self-assembly. However, the self-assembly of amino acids, peptides, and proteins forms amyloid fibrils, resulting in various disorders, most notably neurodegenerative ailments. Examples include the self-assembly of phenylalanine, which causes phenylketonuria; Aβ, which causes Alzheimer's disease; the tau protein, which causes both Alzheimer's and Parkinson's diseases; and α-synuclein, which causes Parkinson's illness. This review provides information related to phytochemicals of great significance that can prevent the formation of, or destabilize, amino acid, peptide, and protein self-assemblies.PMID:37858630 | DOI:10.1016/j.drudis.2023.103802

Source: Drug Discovery Today - October 20, 2023 Category: Drugs & Pharmacology Authors: Jenat Pazheparambil Jerom Soorylekshmi Madhukumar Raveendran Harikumaran Nair Sunilkumar Puthenpurackal Narayanan Source Type: research