Differences in responses to the intracellular macrophage environment between Mycobacterium bovis BCG vaccine strains Moreau and Pasteur

CONCLUSION: Overall, our results show that, compared to Pasteur, BCG Moreau has increased fitness and better endurance in the harsh intracellular environment, also regulating anti-microbial responses (lower IL-1b and MCP-1). These findings contribute to the understanding of the physiology of BCG Moreau and Pasteur in response to the intraphagosomal environment in a THP-1 macrophage model.PMID:37851722 | DOI:10.1590/0074-02760230070

Source: Memorias do Instituto Oswaldo Cruz - October 18, 2023 Category: Infectious Diseases Authors: Paloma Rezende Corr êa Marcos Gustavo Araujo Schwarz Renata Monteiro Maia F átima Maria Figueroa Vergara Milton Oz ório Moraes Leila Mendon ça-Lima Source Type: research