Chronic NF-κB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats

Conclusions:
Our present study indicates blockade of NF-κB, via inhibition of binding of NF-κB with AT1R promoter, reduces renal AT1R expression and function, improves oxidative stress and inflammatory/anti-inflammatory balance, therefore, lowers blood pressure and recovers renal function in ZDF rats.

Source: Cardiovascular Diabetology - June 10, 2015 Category: Cardiology Authors: Hao LuoXinquan WangJialiang WangCaiyu ChenNa WangZaicheng XuShuo ChenChunyu Zeng Source Type: research