Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice

Conclusions
OPN upregulation during liver injury is a conserved repair response, and influences liver progenitor cell function. OPN-neutralisation abrogates the liver progenitor cell response and fibrogenesis in mouse models of liver fibrosis.

Source: Gut - June 9, 2015 Category: Gastroenterology Authors: Coombes, J. D., Swiderska-Syn, M., Dolle, L., Reid, D., Eksteen, B., Claridge, L., Briones-Orta, M. A., Shetty, S., Oo, Y. H., Riva, A., Chokshi, S., Papa, S., Mi, Z., Kuo, P. C., Williams, R., Canbay, A., Adams, D. H., Diehl, A. M., van Grunsven, L. A., Tags: Cirrhosis Hepatology Source Type: research