The Neuropeptide alpha-Melanocyte Stimulating Hormone ( α-MSH) Prevents Persistent Corneal Edema Following Injury

In this study, we investigate the efficacy of the neuropeptide alpha-melanocyte stimulating hormone (α-MSH) in promoting endothelial regeneration during the critical window between ocular injury and the onset of endothelial decompensation using an established murine model of injury using transcorneal freezing. Local administration of α-MSH following injury prevented corneal edema and opacity, reduced leukocyte infiltration, and limited CEnC apoptosis while promoting their proliferation. Our results suggest that α-MSH has pro-regenerative and cytoprotective function on CEnC and shows a promise as a therapy for prevention and management of corneal endothelial dysfunction.PMID:37827217 | DOI:10.1016/j.ajpath.2023.09.007

Source: The American Journal of Pathology - October 12, 2023 Category: Pathology Authors: Hamid Alemi Shudan Wang Tomas Blanco Francesca Kahale Rohan Bir Singh Gustavo Ortiz Aytan Musayeva Erdem Yuksel Kunpeng Pang Neha Deshpande Thomas H Dohlman Ula V Jurkunas Jia Yin Reza Dana Source Type: research