Exploratory Analysis of the Effects of Celecoxib on Cognitive Function in Vortioxetine-Treated Patients With Major Depressive Disorder in the PREDDICT Study: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Conclusions: Both treatment groups showed a reduction in depression-associated cognitive impairment. No superior clinical effect was reported for the add-on celecoxib group. HsCRP was modulated by neither vortioxetine nor add-on celecoxib.Trial Registration: ANZCTR identifier: ACTRN12617000527369.PMID:37796652 | DOI:10.4088/JCP.23m14829

Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Emma Sampson Natalie T Mills Hikaru Hori Kathrin Schwarte Christa Hohoff Oliver Schubert Scott R Clark C élia Fourrier Bernhard T Baune Source Type: research