Mechanism of Troponin release in “ Marathon runners ” ?

Can you believe that 68% of marathon runners show elevated Troponin levels after crossing the finish line? . 11% of them have significant levels that could lead to a diagnosis of ACS if they experience chest pain and end up in the hospital. (Fortescue EB 2007 ) Clinical experience suggest, that it doesn’t require a marathon race to bring troponins into the bloodstream. Any heavy, prolonged physical exertion can potentially release these biomarkers. How much Troponins are released in these runners ? (Ref 3) Most runners (68%) had some degree of  troponin increase (troponin T > or = 0.01 ng/mL or troponin I > or = 0.1 ng/mL), and 55 (11%) had significant increases (troponin T > or = 0.075 ng/mL or troponin I > or = 0.5 ng/mL)) Troponin distribution within myocyte Troponins are structural cardaic protiens. 90 % are attached to contractile elements. Free floating troponin in cytoplasm (myoplasm) are detected in about 6–8% for cTnT and 3.5% for cTnI Gaze DC, Collinson PO. Multiple molecular forms of circulating cardiac troponin: analytical and clinical significance. Annals of Clinical Biochemistry. 2008;45(4):349-355. doi:10.1258/acb.2007.00722 Mechanism of Troponin leak Why should a hale and healthy person , (in fact a super normal humans) release cardaic Troponin into blood stream ? The following are the putative mechanism mentioned in the best availabe literature.(Ref 1) An increased cardiomyocyte ...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Uncategorized cardaic biomarkers free cytosolic troponin mechansim troponin release non cardiac troponin troponin in marathon runners troponin t vs i Source Type: blogs