Serological Screening for Celiac Disease and Gastrointestinal Absorption Disorders in Patients with Autoimmune Endocrine Diseases
This study aimed to evaluate the frequency of clinically overt or
silent CD in patients diagnosed with autoimmune endocrinopathy and the clinical
effects of silent CD in these endocrinopathies. The study included 166 patients
with known or newly diagnosed mono-/polyglandular AED and 90 age- and
gender-matched healthy controls. The patients were classified into four groups:
type 1 diabetes mellitus (DM) (n=44), Hashimoto’s thyroiditis
(HT) (n=68), Addison’s disease (AD) (n=17), and
autoimmune polyglandular syndrome (APS) (n=37). All subjects were
serologically screened for tissue transglutaminase antibody (tTG) IgA and IgG.
In addition, to evaluate the possible systemic consequences of CD, serum
parathormone (PTH), 25-hydroxicholecalsiferol (25-OH-Vit D), vitamin B12, folic
acid, iron, iron-binding capacity (IBC), and ferritin levels were measured. In
the total series, 193 (75.4%) individuals were females, and 63
(24.6%) were males. TTG IgA antibody positivity was found in 23 among
166 patients, while no positivity was encountered in the healthy control group.
The highest rates of positive tTg IgA frequency were detected in AD, with
29.4% (5/17). Serum 25-OH-Vit D, vitamin B12, folic acid, iron,
and ferritin levels were significantly lower in AEDs compared to controls
(p<0.001), and the lowest...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Akkurt Kocaeli, Aysen Cander, Soner G ül, Özen Öz Sisman, P ınar Ersoy, Canan Erturk, Erd ınc Tags: Original Article: Endocrine Care Source Type: research
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