MiR-455-3p mediates PPAR α through UBN2 to promote apoptosis and autophagy in acute myeloid leukemia cells

Acute myeloid leukemia (AML) is a hackneyed type of acute leukemia that is a highly specific, invasive, and rare tumor[1-3]. Its characteristics are aberrant proliferation of original or immature cells in blood, bone marrow and other tissues, stasis of differentiation, and dysfunction of cell apoptosis, leading to restraint of normal hematopoietic function[4]. At present, the first-line remedy for AML is chiefly based on combination chemotherapy and stem cell transplantation. Despite significant progress in AML treatment, the overall survival rate is still low [2, 5].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Article Source Type: research