Anti-prolactin treatment alleviates lupus conditions by regulating the JAK2-STAT3 pathway

CONCLUSIONS: In summary, these data suggest that PRL inhibition alleviates lupus-like disease in MRL/lpr mice by modulating the Jak2-Stat3 signalling cascade. More importantly, our results imply the potential of PRL inhibitors and may provide a novel therapeutic approach for lupus.PMID:37727880 | DOI:10.1111/1440-1681.13818

Source: Clinical and Experimental Pharmacology and Physiology - September 20, 2023 Category: Drugs & Pharmacology Authors: Ying Jiang Huyan Chen Jinran Lin Jiewen Pan Yanyun Shen Qiao Li Source Type: research