Greens Appraisal of Validated Stability Indicating RP-HPLC Method and Forced Degradation Study for Quantification of Ebastine in Wastewater and Dosage Form

CONCLUSION: According to International Council for Harmonisation (ICH) guidelines, a forced degradation study of EBS was evaluated, including acid, base hydrolysis, and oxidative hydrolysis using hydrogen peroxide and photolytic and thermal degradation. The highest degradation was achieved by acid hydrolysis. The safety and efficacy of EBS were evaluated via a safety comparative profile study.PMID:37739216 | DOI:10.1016/j.pharma.2023.09.004

Source: Annales Pharmaceutiques Francaises - September 22, 2023 Category: Drugs & Pharmacology Authors: Manal A Almalki Tahani Ya Alanazi Samar M Mahgoub Fatma I Abo El-Ela Mahmoud A Mohamed Source Type: research