Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex

In this study, we found that disease-associated inclusions induced by elongated polyglutamine chains disrupt the complex formation of BAG6 with UBL4A, a mammalian homologue of yeast Get5. UBL4A also dissociated from BAG6 in response to proteotoxic stresses such as proteasomal inhibition and mitochondrial depolarization. These findings imply that the cytotoxicity of pathological protein aggregates might be attributed in part to disruption of the BAG6-UBL4A complex that is required for the biogenesis of tail-anchored proteins.PMID:37747814 | DOI:10.1042/BCJ20230267
Source: The Biochemical Journal - Category: Biochemistry Authors: Source Type: research