Bleomycin-treated myoblasts undergo p21-associated cellular senescence and have severely impaired differentiation

In conclusion, bleomycin treatment provides a valid model of damage-induced senescence that was associated with elevated p21, reduced myoblast proliferation, and aberrant cell cycle kinetics, while confirming that a multi-marker approach is needed for the accurate classification of senescence within skeletal muscle.
Source: AGE - Category: Geriatrics Source Type: research